Age features of functional condition of microvessel endothelia

  • Ivanna Antoniuk-Shcheglova D. F. Chebotarev Institute of Gerontology NAMS of Ukraine, Kyiv, Ukraine
  • Olena Bondarenko D. F. Chebotarev Institute of Gerontology NAMS of Ukraine, Kyiv, Ukraine
  • Georgij Duzhak D. F. Chebotarev Institute of Gerontology NAMS of Ukraine, Kyiv, Ukraine
  • Oleg Korkushko D. F. Chebotarev Institute of Gerontology NAMS of Ukraine, Kyiv, Ukraine
  • Svitlana Naskalova D. F. Chebotarev Institute of Gerontology NAMS of Ukraine, Kyiv, Ukraine
  • Larysa Bodretska D. F. Chebotarev Institute of Gerontology NAMS of Ukraine, Kyiv, Ukraine
  • Iryna Shapovalenko D. F. Chebotarev Institute of Gerontology NAMS of Ukraine, Kyiv, Ukraine
  • Valeri Shatilo D. F. Chebotarev Institute of Gerontology NAMS of Ukraine, Kyiv, Ukraine
Keywords: functional state of the endothelium; platelet aggregation

Abstract

Our research aimed to investigate age-related changes in the functional state of the microvascular endothelium.Матеріали та методи.  390 people were surveyed, divided by age into the following groups: 20-29 (n = 31), 30-39 (n = 22), 40-49 (n = 45), 50-59 (n = 72), 60- 69 (n = 129) and 70-79 years (n = 91). The functional state of the microvascular endothelium was studied by laser Doppler flowmetry (LDF) on the BLF-21D (Transonic Systems Inc, USA) in the middle third of the inner surface of the forearm. The turbidimetric method studied platelet aggregation activity on a two-channel laser platelet aggregation analyzer 23 LA (Biola, Russia).  Blood viscosity was determined using a rotary viscometer AKR-2 (Russia) at shear rates of 10-200 s-1 with the calculation of the deformation index (IDE) and erythrocyte aggregation index (IAE). As a result of the research, it was found that there was a statistically significant decrease in the cutaneous rate of skin blood flow volumetric velocity (SBF) at rest and at the peak of post-occlusive reactive hyperemia, as well as a reduction in the recovery time of the CMT to baseline. indicating endothelial dysfunction with ageing from the age of 50-59 years. In persons older than 60 years there is an increase in endothelial dysfunction, which is accompanied by deterioration of hemostasis: increased blood viscosity, increased both spontaneous and induced platelet aggregation activity. Blood viscosity increases statistically significantly from the age of 40. We have drawn the following conclusions: the development of endothelial dysfunction with ageing is characterized by changes in the vasomotor function of the endothelium, its antiplatelet, antiadhesive and antithrombotic properties, which leads to the development of vascular pathology in the elderly.

Author Biographies

Ivanna Antoniuk-Shcheglova , D. F. Chebotarev Institute of Gerontology NAMS of Ukraine, Kyiv, Ukraine

DSc (Medicine), Leading Researcher of the Department of Clinical Physiology and Pathology of Internal Organs

Olena Bondarenko, D. F. Chebotarev Institute of Gerontology NAMS of Ukraine, Kyiv, Ukraine

PhD (Medicine), Senior Researcher of the Department of Clinical Physiology and Pathology of Internal Organs

Georgij Duzhak, D. F. Chebotarev Institute of Gerontology NAMS of Ukraine, Kyiv, Ukraine

PhD (Medicine), Senior Researcher of the Department of Clinical Physiology and Pathology of Internal Organs

Oleg Korkushko, D. F. Chebotarev Institute of Gerontology NAMS of Ukraine, Kyiv, Ukraine

DSc (Medicine), Prof., Cor. Member of the NAS of Ukraine,  Full Member of the NAMS of Ukraine, Head of the Department of Clinical Physiology and Pathology of Internal Organs

Svitlana Naskalova, D. F. Chebotarev Institute of Gerontology NAMS of Ukraine, Kyiv, Ukraine

PhD (Medicine), Senior Researcher of the Department of Clinical Physiology and Pathology of Internal Organs

Larysa Bodretska, D. F. Chebotarev Institute of Gerontology NAMS of Ukraine, Kyiv, Ukraine

PhD  (Medicine), Leading  Researcher  of  the  Department  of  Clinical  Physiology  and Pathology of Internal Organs

Iryna Shapovalenko, D. F. Chebotarev Institute of Gerontology NAMS of Ukraine, Kyiv, Ukraine

PhD (Medicine), Researcher of the Department of Clinical Physiology and Pathology of Internal Organs

Valeri Shatilo, D. F. Chebotarev Institute of Gerontology NAMS of Ukraine, Kyiv, Ukraine

DSc (Medicine), Prof., Leading Researcher of the Department of Clinical Physiology and Pathology of Internal Organs, Deputy Director for Research

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Published
2022-04-05
How to Cite
Antoniuk-Shcheglova , I., Bondarenko, O., Duzhak, G., Korkushko, O., Naskalova, S., Bodretska, L., Shapovalenko, I., & Shatilo, V. (2022). Age features of functional condition of microvessel endothelia. Ageing and Longevity, 3(1), 8-13. Retrieved from http://aging-longevity.org.ua/journal-description/article/view/46
Section
Статьи

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