Age peculiarities of pharmacokinetics and pharmacodynamics of medicines

Liana Kuprash; Svetlana Gudarenko; Olena Kuprash; Nadiya Gorchakova; Olena Khodakivska

Liana Kuprash DSc (Medicine), Head of the Geriatric Pharmacology Laboratory of the State Institution “D. F. Chebotarev Institute of Gerontology NAMS of Ukraine”
Svetlana Gudarenko Researcher of the Laboratory of Geriatric Pharmacology of the State Institution “D. F. Chebotarev Institute of Gerontology NAMS of Ukraine”
Olena Kuprash MD, PhD (Medicine), Department of Clinical and Epidemiological Cardiology of the State Institution “D. F. Chebotarev Institute of Gerontology NAMS of Ukraine”
Nadiya Gorchakova DSc (Medicine), Prof. of the Department of Pharmacology with a course in clinical pharmacology of the Bogomolets National Medical University
Olena Khodakivska MD, PhD (Medicine), Bogomolets National Medical University

Keywords: Drug therapy, pharmacokinetics of medicines, pharmacodynamics of medicines, aging

Abstract

Abstract. The drug therapy of elderly and senile patients is characterized by a number of features due to morphological, metabolic and functional disorders that occur in the body during aging at all levels of the body's life activity: the molecular genetic level, cellular level, the organ level, the regulatory level. As a result, the drugs’ pharmacokinetics and pharmacodynamics of drugs change which has a significant impact on the effectiveness and safety of drug therapy in elderly and senile patients

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