Age peculiarities of pharmacokinetics and pharmacodynamics of medicines

  • Liana Kuprash DSc (Medicine), Head of the Geriatric Pharmacology Laboratory of the State Institution “D. F. Chebotarev Institute of Gerontology NAMS of Ukraine”
  • Svetlana Gudarenko Researcher of the Laboratory of Geriatric Pharmacology of the State Institution “D. F. Chebotarev Institute of Gerontology NAMS of Ukraine”
  • Olena Kuprash MD, PhD (Medicine), Department of Clinical and Epidemiological Cardiology of the State Institution “D. F. Chebotarev Institute of Gerontology NAMS of Ukraine”
  • Nadiya Gorchakova DSc (Medicine), Prof. of the Department of Pharmacology with a course in clinical pharmacology of the Bogomolets National Medical University
  • Olena Khodakivska MD, PhD (Medicine), Bogomolets National Medical University
Keywords: Drug therapy, pharmacokinetics of medicines, pharmacodynamics of medicines, aging


Abstract. The drug therapy of elderly and senile patients is characterized by a number of features due to morphological, metabolic and functional disorders that occur in the body during aging at all levels of the body's life activity: the molecular genetic level, cellular level, the organ level, the regulatory level. As a result, the drugs’ pharmacokinetics and pharmacodynamics of drugs change which has a significant impact on the effectiveness and safety of drug therapy in elderly and senile patients


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How to Cite
Kuprash, L., Gudarenko, S., Kuprash, O., Gorchakova, N., & Khodakivska, O. (2020). Age peculiarities of pharmacokinetics and pharmacodynamics of medicines. Ageing and Longevity, 1(1). Retrieved from