Therapeutic hypercapnia. Review

  • Denis Tolstun D. F. Chebotarev Institute of Gerontology NAMS of Ukraine, Kyiv, Ukraine
  • Khachik Muradian D. F. Chebotarev Institute of Gerontology NAMS of Ukraine, Kyiv, Ukraine
  • Vladislav Bezrukov D. F. Chebotarev Institute of Gerontology NAMS of Ukraine, Kyiv, Ukraine
Keywords: hypercapnia; hypoxia; cancer; diabetes; neuroprotection; longevity; carboxytherapy; ischemia; stroke


In recent years, interest in hypercapnia and its practical applications has grown significantly. An analysis of literature data shows a wide range of systemic and local applications. Due to its powerful effect on blood circulation, vascular elasticity, activation of angiogenesis, and inhibition of pro-inflammatory factors, hypercapnia is already used in dermatology, phlebology, and therapy. Wide opportunities open up for practical use in neurology, given the powerful neuroprotective effect of carbon dioxide, which not only increases tolerance to ischemia, preventing the development of diseases but can also become a tool for the treatment of stroke and heart attack. The antitumor effect and the ability to reduce the level of metabolic processes also make hypercapnia an attractive geroprotector that will help in solving the issue of life extension.

Author Biographies

Denis Tolstun, D. F. Chebotarev Institute of Gerontology NAMS of Ukraine, Kyiv, Ukraine

PhD (Biology), Leading Researcher of the of the Department of Biology of Aging and Experimental Life Extension

Khachik Muradian, D. F. Chebotarev Institute of Gerontology NAMS of Ukraine, Kyiv, Ukraine

DSc (Biology), Chief Researcher of of the Department of Biology of Aging and Experimental Life Extension

Vladislav Bezrukov, D. F. Chebotarev Institute of Gerontology NAMS of Ukraine, Kyiv, Ukraine

MD, DSc (Medicine), Prof., Full Member (Academician) of the NAMS of Ukraine, Director of the State Institution “D. F. Chebotarev Institute of Gerontology NAMS of Ukraine”, Head of the Department of Biology of Aging and Experimental Life Extension


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How to Cite
Tolstun, D., Muradian, K., & Bezrukov, V. (2022). Therapeutic hypercapnia. Review. Ageing and Longevity, 3(3), 101-113. Retrieved from