Response of some indicators of the respiratory system to dosed hypoxia in elderly people with impaired glucose tolerance
Abstract
The response of the respiratory system to dosed hypoxia (breathing with a gas mixture of 12% oxygen for 20 min) in the elderly with impaired (n = 35) and preserved glucose tolerance (n = 33) was studied. It is shown that the increase in lung ventilation occurs regardless of the state of carbohydrate metabolism in hypoxia. In people with impaired glucose tolerance, changes in lung ventilation in hypoxia are less significant than in people with persistent glucose tolerance. In persons with impaired glucose tolerance, an inverse relationship was found between the increase in pulmonary ventilation during hypoxia and insulin resistance (r = -0.26, p = 0.035), as well as between the increase in pulmonary ventilation during hypoxia and plasma glucose concentration due to 2 hours of standard glucose tolerance test (r = -0.31, p = 0.012). It is concluded that there is a causal relationship between impaired glucose tolerance and insufficient response of pulmonary ventilation to hypoxia in the elderly.
References
La Vignera, S.; Aversa, A.; Monzani, F. Endocrine Frailty in the Elderly. Frontiers Media SA 2019, p 147. https://doi.org/10.3389/978-2-88963-234-3
Smith, N. L.; Savage, P. J.; Heckbert, S. R. et al. Glucose, blood pressure, and lipid control in older people with and without diabetes mellitus: the Cardiovascular Health Study. J Am Geriatr Soc 2002, 50, 3, 416-23. https://doi.org/10.1046/j.1532-5415.2002.50103.x
Nyengaard, J. R; Ido, Y.; Kilo, C.; Williamson, J. R. Interactions between hyperglycemia and hypoxia: implications for diabetic retinopathy. Diabetes 2004, 53, 11, 2931-2938. https://doi.org/10.2337/diabetes.53.11.2931
Dyer, C. The interaction of ageing and lung disease. Chron Respir Dis 2012, 9, 1, 63-67. https://doi.org/10.1177/1479972311433766
Korkushko, O. V.; Asanov, E. O.; Pisaruk, A. V.; Chebotarev, N. D. Changes in ventilation during hypoxia in the elderly with physiological and accelerated aging of the respiratory system. Ukr. pulmonol. jour. 2009, 3, 33-35. (in Russian)
American Diabetes Association. 2. Classification and Diagnosis of Diabetes: Standards of Medical Care in Diabetes-2021. Diabetes Care 2021, 44, 1, S15-S33. https://doi.org/10.2337/dc21-S002
Kolchynskaya, A. Z.; Tsyganova, T. N.; Ostapenko, L. A. Normobaric interval hypoxic training in medicine and sport. Medicina: Moscow, 2003:408. (in Russian)
Erecińska, M.; Silver, I. A. Tissue oxygen tension and brain sensitivity to hypoxia. Respiration physiology 2001, 128, 3, 263-276. https://doi.org/10.1016/s0034-5687(01)00306-1
Duelli, R.; Kuschinsky, W. Brain glucose transporters: relationship to local energy demand. News Physiol Sci 2001, 16, 71-76. https://doi.org/10.1152/physiologyonline.2001.16.2.71
Plum, L.; Schubert, M.; Brüning, J. The role of insulin receptor signalling in the brain. Trends in Endocrinology & Metabolism 2005, 16, 2, 59-65. https://doi.org/10.1016/j.tem.2005.01.008
Dekker, N. Outer-membrane phospholipase A: known structure, unknown biological function. Molecular microbiology 2000, 35, 4, 711–717. https://doi.org/10.1046/j.1365-2958.2000.01775.x
Ditzel, J. The problems of tissue oxygenation in diabetes mellitus. III. The "three-in-one concept" for the development of diabetic microangiopathy and a rational approach to its prophylaxis. Acta Med Scand Suppl 1975, 578, 69-83.