Response of some indicators of the respiratory system to dosed hypoxia in elderly people with impaired glucose tolerance

  • Anna Havalko D. F. Chebotarev Institute of Gerontology NAMS of Ukraine, Kyiv, Ukraine
  • Ervin Asanov D. F. Chebotarev Institute of Gerontology NAMS of Ukraine, Kyiv, Ukraine
  • Valeri Shatilo D. F. Chebotarev Institute of Gerontology NAMS of Ukraine, Kyiv, Ukraine
Keywords: elderly; impaired glucose tolerance; hypoxia; ventilation

Abstract

The response of the respiratory system to dosed hypoxia (breathing with a gas mixture of 12% oxygen for 20 min) in the elderly with impaired (n = 35) and preserved glucose tolerance (n = 33) was studied. It is shown that the increase in lung ventilation occurs regardless of the state of carbohydrate metabolism in hypoxia. In people with impaired glucose tolerance, changes in lung ventilation in hypoxia are less significant than in people with persistent glucose tolerance. In persons with impaired glucose tolerance, an inverse relationship was found between the increase in pulmonary ventilation during hypoxia and insulin resistance (r = -0.26, p = 0.035), as well as between the increase in pulmonary ventilation during hypoxia and plasma glucose concentration due to 2 hours of standard glucose tolerance test (r = -0.31, p = 0.012). It is concluded that there is a causal relationship between impaired glucose tolerance and insufficient response of pulmonary ventilation to hypoxia in the elderly.

Author Biographies

Anna Havalko, D. F. Chebotarev Institute of Gerontology NAMS of Ukraine, Kyiv, Ukraine

Junior Scientific Researcher, Department of Clinical Physiology and Pathology of Internal Organs

Ervin Asanov, D. F. Chebotarev Institute of Gerontology NAMS of Ukraine, Kyiv, Ukraine

DSc (Medicine), Principal Scientific Researcher of the Department of Clinical Physiology and Pathology of Internal Organs

Valeri Shatilo, D. F. Chebotarev Institute of Gerontology NAMS of Ukraine, Kyiv, Ukraine

DSc (Medicine), Prof., Leading Researcher of the Department of Clinical Physiology and Pathology of Internal Organs, Deputy Director for Research

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Published
2022-04-18
How to Cite
Havalko, A., Asanov, E., & Shatilo, V. (2022). Response of some indicators of the respiratory system to dosed hypoxia in elderly people with impaired glucose tolerance. Ageing and Longevity, 3(1), 27-31. Retrieved from http://aging-longevity.org.ua/index.php/journal-description/article/view/48
Section
Статьи

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