Estimating biological age of the autonomic regulation cardio-vascular system
Abstract. Based on our data on age-related changes in blood pressure, ECG, and HRV, we developed a method for assessing the cardiovascular system's biological (functional) age. We set ourselves the task of finding a simple non-invasive method for the integral assessment of the state of the cardiovascular system, which allows us to quantify the degree of age-related changes in this system. The essence of the method lies in the fact that the BA of the cardiovascular system is calculated according to the indicators of BP, QT and HRV. The study included 108 practically healthy people aged from 20 to 90 years. The formula for calculating BA was obtained by multiple stepwise regression. The multiple correlation between biological age and chronological is high (r = 0.895; p <0.00001). The average absolute value of the error of BA calculation, in this case, is 5.19 years. Thus, the method for assessing the rate of ageing developed by us has high accuracy and can be used to assess the risk of developing age-dependent cardiovascular pathology. The implementation of the proposed method will allow not only to identify people with the risk of developing pathology but also to assess the effectiveness of treatment, prophylactic and rehabilitation measures.
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