Statins in preventing stroke

  • Viktor Kuznetsov D. F. Chebotarev Institute of Gerontology NAMS of Ukraine
Keywords: ischemic stroke; statins; bioelectric activity of the brain; cerebral blood flow; atherothrombotic ischemic stroke


Abstact. The results of a comprehensive analysis of Simvastatin (at a dose of 20 mg per day) on the functional state of the brain in patients with atherothrombotic ischemic stroke are presented.  Simvastatin provokes vasoactive action (increases linear rate of systolic blood flow velocity (LBFVsys) and decreases peripheral resistance in separate vessels of the carotid and vertebra-basilar basins), posseses antiatherogenic action (a drug decrease in the intima size, in the frequency of the atherosclerotic plagues, in the level of cholesterol, triglycerides and  low density lipoproteids (LDLs). This medication leads to a positive reorganization of the bioelectric activity of the brain (increases the frequency of alpha rhythm and decreases the power of the slow rhythms), being more marked in the patients with a left-sided ischemic localization. Complex positive effects of the Simvastatin on the cerebral hemodynamic, bioelectric activity of the brain and lipid metabolism in the patients after athrothrombotic ischemic stroke allow us to recommend Simvastatin not only for  the secondary prevention of stroke but also for the correction of CNS functioning in stroke patients during their rehabilitation.

Author Biography

Viktor Kuznetsov, D. F. Chebotarev Institute of Gerontology NAMS of Ukraine

DSc (Medicine), Leading Researcher of Department of Vascular Pathology of the Brain, Department of Rehabilitation of Neurological Patients; Web of Science Researcher ID W-9357-2019



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How to Cite
Kuznetsov, V. (2020). Statins in preventing stroke. Ageing and Longevity, 1(2), 72-81. Retrieved from